منابع مشابه
Gastrointestinal Cancer
Learning Objectives After completing this course, the reader will be able to: 1. Discuss the epidemiology of esophageal cancer. 2. Explain the current status of diagosing and treating esophageal cancer. 3. Describe potential novel targets for new drug development in esophageal cancer. Abstract Esophageal cancer is a highly aggressive neoplasm. In 2005, 14,520 Americans will be diagnosed with es...
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Colorectal cancer (CRC) is a major public health problem (1,200,000 new cases per year worldwide) and increasingly affects older people; the current median age at diagnosis is 71, and for CRC-related death is 75 years. After 50 years of age, the incidence doubles every seven years, and 76% of patients with newly diagnosed CRC are between 65 and 85 years of age. The liver is the most common site...
متن کاملGastrointestinal Cancer
Colorectal cancer (CRC) is the third most commonly diagnosed malignancy in the world. Screening for CRC or its precursor lesions (adenomas) by endoscopy with polypectomy has been shown to reduce CRC incidence and mortality. More vigilant screening and surveillance by colonoscopy is recommended for certain high-risk populations, for example patients with a positive family history of CRC and thos...
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Cancer cells exhibit altered glucose metabolism, mitochondrial dysfunction, anaerobic glycolysis and upregulation of the pentose phosphate pathway (PPP). Recent genetic and metabolic analyses have provided insights into the molecular mechanisms of genes that are involved in the alteration of cancer metabolism and tumorigenesis. Hypoxic induced factor 1 regulates the reciprocal relationship betw...
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1Department of Gastroenterology, School of Medicine, Shanghai East Hospital, Tongji University, Shanghai 200120, China 2Division of Digestive Surgery, Department of General Surgery, Medical School, Hospital de Cĺınicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil 3Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hosp...
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ژورنال
عنوان ژورنال: Gut
سال: 2005
ISSN: 0017-5749
DOI: 10.1136/gut.2005.078188